Basophils are required for the induction of Th2 immunity to haptens and peptide antigens

Atsushi Otsuka, Saeko Nakajima, Masato Kubo, Gyohei Egawa, Tetsuya Honda, Akihiko Kitoh, Takashi Nomura, Sho Hanakawa, Catharina Sagita Moniaga, Bongju Kim, Satoshi Matsuoka, Takeshi Watanabe, Yoshiki Miyachi and Kenji Kabashima ()
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Atsushi Otsuka: Kyoto University Graduate School of Medicine
Saeko Nakajima: Kyoto University Graduate School of Medicine
Masato Kubo: Laboratory for Cytokine Regulation, Integrative Medical Science (IMS), RIKEN Yokohama Institute
Gyohei Egawa: Kyoto University Graduate School of Medicine
Tetsuya Honda: Kyoto University Graduate School of Medicine
Akihiko Kitoh: Kyoto University Graduate School of Medicine
Takashi Nomura: Kyoto University Graduate School of Medicine
Sho Hanakawa: Kyoto University Graduate School of Medicine
Catharina Sagita Moniaga: Kyoto University Graduate School of Medicine
Bongju Kim: Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine
Satoshi Matsuoka: Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine
Takeshi Watanabe: Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine
Yoshiki Miyachi: Kyoto University Graduate School of Medicine
Kenji Kabashima: Kyoto University Graduate School of Medicine

Nature Communications, 2013, vol. 4, issue 1, 1-9

Abstract: Abstract The relative contributions of basophils and dendritic cells in Th2 skewing to foreign antigen exposure remain unclear. Here we report the ability of basophils to induce Th2 polarization upon epicutaneous sensitization with different antigens using basophil conditionally depleted Bas TRECK transgenic mice. Basophils are responsible for Th2 skewing to haptens and peptide antigens, but not protein antigens in vivo. Consistent with this, basophils cannot take up or process ovalbumin protein in significant quantities, but present ovalbumin peptide to T cells for Th2 differentiation via major histocompatibility complex class II. Intriguingly, basophils promote Th2 skewing upon ovalbumin protein exposure in the presence of dendritic cells. Taken together, our results suggest that basophils alone are able to induce Th2 skewing with haptens and peptide antigens but require dendritic cells for the induction of Th2 for protein antigens upon epicutaneous immunization.

Date: 2013
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DOI: 10.1038/ncomms2740

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