Competing signals drive telencephalon diversity

J B. Sylvester, C A. Rich, C Yi, J N. Peres, C Houart and J T. Streelman ()
Additional contact information
J B. Sylvester: Parker H. Petit Institute for Bioengineering and Biosciences, School of Biology, Georgia Institute of Technology
C A. Rich: Parker H. Petit Institute for Bioengineering and Biosciences, School of Biology, Georgia Institute of Technology
C Yi: Parker H. Petit Institute for Bioengineering and Biosciences, School of Biology, Georgia Institute of Technology
J N. Peres: Medical Research Council Centre for Developmental Neurobiology, King’s College London
C Houart: Medical Research Council Centre for Developmental Neurobiology, King’s College London
J T. Streelman: Parker H. Petit Institute for Bioengineering and Biosciences, School of Biology, Georgia Institute of Technology

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract The telencephalon is the most complex brain region, controlling communication, emotion, movement and memory. Its adult derivatives develop from the dorsal pallium and ventral subpallium. Despite knowledge of genes required in these territories, we do not understand how evolution has shaped telencephalon diversity. Here, using rock- and sand-dwelling cichlid fishes from Lake Malawi, we demonstrate that differences in strength and timing of opposing Hedgehog and Wingless signals establish evolutionary divergence in dorsal–ventral telencephalon patterning. Rock dwellers exhibit early, extensive Hedgehog activity in the ventral forebrain resulting in expression of foxg1 before dorsal Wingless signals, and a larger subpallium. Sand dwellers show rapid deployment of Wingless, later foxg1 expression and a larger pallium. Manipulation of the Hedgehog and Wingless pathways in cichlid and zebrafish embryos is sufficient to mimic differences between rock- versus sand-dweller brains. Our data suggest that competing ventral Hedgehog and dorsal Wingless signals mediate evolutionary diversification of the telencephalon.

Date: 2013
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms2753 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2753

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms2753

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().