The genomics of selection in dogs and the parallel evolution between dogs and humans

Guo-dong Wang, Weiwei Zhai, He-chuan Yang, Ruo-xi Fan, Xue Cao, Li Zhong, Lu Wang, Fei Liu, Hong Wu, Lu-guang Cheng, Andrei D. Poyarkov, Nikolai A. Poyarkov, Shu-sheng Tang, Wen-ming Zhao, Yun Gao, Xue-mei Lv, David M. Irwin, Peter Savolainen, Chung-I Wu () and Ya-ping Zhang ()
Additional contact information
Guo-dong Wang: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Weiwei Zhai: Center for Computational Biology and Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
He-chuan Yang: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Ruo-xi Fan: Laboratory for Conservation and Utilization of Bio-resources, Yunnan University
Xue Cao: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Li Zhong: Laboratory for Conservation and Utilization of Bio-resources, Yunnan University
Lu Wang: Laboratory for Conservation and Utilization of Bio-resources, Yunnan University
Fei Liu: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Hong Wu: Laboratory for Conservation and Utilization of Bio-resources, Yunnan University
Lu-guang Cheng: Kunming Police Dog Base, Ministry of Public Security, Heilongtan
Andrei D. Poyarkov: Severtsov Institute of Ecology and Evolution, Russian Academy of Science
Nikolai A. Poyarkov: Faculty of Biology, M.V. Lomonosov Moscow State University
Shu-sheng Tang: Kunming Police Dog Base, Ministry of Public Security, Heilongtan
Wen-ming Zhao: Center for Computational Biology and Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
Yun Gao: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Xue-mei Lv: Center for Computational Biology and Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
David M. Irwin: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Peter Savolainen: School of Biotechnology, KTH Royal Institute of Technology, Science for Life Laboratory, Tomtebodavägen 23A
Chung-I Wu: Center for Computational Biology and Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
Ya-ping Zhang: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences

Nature Communications, 2013, vol. 4, issue 1, 1-9

Abstract: Abstract The genetic bases of demographic changes and artificial selection underlying domestication are of great interest in evolutionary biology. Here we perform whole-genome sequencing of multiple grey wolves, Chinese indigenous dogs and dogs of diverse breeds. Demographic analysis show that the split between wolves and Chinese indigenous dogs occurred 32,000 years ago and that the subsequent bottlenecks were mild. Therefore, dogs may have been under human selection over a much longer time than previously concluded, based on molecular data, perhaps by initially scavenging with humans. Population genetic analysis identifies a list of genes under positive selection during domestication, which overlaps extensively with the corresponding list of positively selected genes in humans. Parallel evolution is most apparent in genes for digestion and metabolism, neurological process and cancer. Our study, for the first time, draws together humans and dogs in their recent genomic evolution.

Date: 2013
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DOI: 10.1038/ncomms2814

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