Draft genome sequence of the Tibetan antelope

Ri-Li Ge, Qingle Cai, Yong-Yi Shen, A San, Lan Ma, Yong Zhang, Xin Yi, Yan Chen, Lingfeng Yang, Ying Huang, Rongjun He, Yuanyuan Hui, Meirong Hao, Yue Li, Bo Wang, Xiaohua Ou, Jiaohui Xu, Yongfen Zhang, Kui Wu, Chunyu Geng, Weiping Zhou, Taicheng Zhou, David M. Irwin, Yingzhong Yang, Liu Ying, Haihua Bao, Jaebum Kim, Denis M. Larkin, Jian Ma, Harris A. Lewin, Jinchuan Xing, Roy N. Platt, David A. Ray, Loretta Auvil, Boris Capitanu, Xiufeng Zhang, Guojie Zhang, Robert W. Murphy, Jun Wang, Ya-Ping Zhang and Jian Wang
Additional contact information
Ri-Li Ge: Key Laboratory for High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University
Qingle Cai: BGI-Shenzhen
Yong-Yi Shen: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
A San: BGI-Shenzhen
Lan Ma: Key Laboratory for High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University
Yong Zhang: BGI-Shenzhen
Xin Yi: BGI-Shenzhen
Yan Chen: BGI-Shenzhen
Lingfeng Yang: BGI-Shenzhen
Ying Huang: BGI-Shenzhen
Rongjun He: BGI-Shenzhen
Yuanyuan Hui: BGI-Shenzhen
Meirong Hao: BGI-Shenzhen
Yue Li: BGI-Shenzhen
Bo Wang: BGI-Shenzhen
Xiaohua Ou: BGI-Shenzhen
Jiaohui Xu: BGI-Shenzhen
Yongfen Zhang: BGI-Shenzhen
Kui Wu: BGI-Shenzhen
Chunyu Geng: BGI-Shenzhen
Weiping Zhou: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
Taicheng Zhou: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
David M. Irwin: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
Yingzhong Yang: Key Laboratory for High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University
Liu Ying: Affiliated Hospital of Qinghai University
Haihua Bao: Affiliated Hospital of Qinghai University
Jaebum Kim: Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Denis M. Larkin: Institute of Biological, Environmental and Rural Sciences, Aberystwyth University
Jian Ma: Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Harris A. Lewin: University of California
Jinchuan Xing: Eccles Institute of Human Genetics, University of Utah School of Medicine
Roy N. Platt: Molecular Biology, Entomology and Plant Pathology, Mississippi State University
David A. Ray: Molecular Biology, Entomology and Plant Pathology, Mississippi State University
Loretta Auvil: National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign
Boris Capitanu: National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign
Xiufeng Zhang: Gerumud Hospital, Gerumud
Guojie Zhang: BGI-Shenzhen
Robert W. Murphy: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
Jun Wang: BGI-Shenzhen
Ya-Ping Zhang: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
Jian Wang: BGI-Shenzhen

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract The Tibetan antelope (Pantholops hodgsonii) is endemic to the extremely inhospitable high-altitude environment of the Qinghai-Tibetan Plateau, a region that has a low partial pressure of oxygen and high ultraviolet radiation. Here we generate a draft genome of this artiodactyl and use it to detect the potential genetic bases of highland adaptation. Compared with other plain-dwelling mammals, the genome of the Tibetan antelope shows signals of adaptive evolution and gene-family expansion in genes associated with energy metabolism and oxygen transmission. Both the highland American pika, and the Tibetan antelope have signals of positive selection for genes involved in DNA repair and the production of ATPase. Genes associated with hypoxia seem to have experienced convergent evolution. Thus, our study suggests that common genetic mechanisms might have been utilized to enable high-altitude adaptation.

Date: 2013
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DOI: 10.1038/ncomms2860

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