MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

Ching-Wen Lin, Yih-Leong Chang, Yu-Chiuan Chang, Jau-Chen Lin, Chun-Chi Chen, Szu-Hua Pan, Chen-Tu Wu, Hsuan-Yu Chen, Shuenn-Chen Yang, Tse-Ming Hong and Pan-Chyr Yang ()
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Ching-Wen Lin: Graduate Institute of Molecular Medicine, College of Medicine, National Taiwan University
Yih-Leong Chang: National Taiwan University
Yu-Chiuan Chang: Institute of Biomedical Sciences, Academia Sinica
Jau-Chen Lin: Fu Jen Catholic University
Chun-Chi Chen: Institute of Biomedical Sciences, Academia Sinica
Szu-Hua Pan: Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University
Chen-Tu Wu: National Taiwan University
Hsuan-Yu Chen: Institute of Statistical Science, Academia Sinica
Shuenn-Chen Yang: Institute of Biomedical Sciences, Academia Sinica
Tse-Ming Hong: Graduate institute of Clinical Medicine, National Cheng Kung University
Pan-Chyr Yang: Graduate Institute of Molecular Medicine, College of Medicine, National Taiwan University

Nature Communications, 2013, vol. 4, issue 1, 1-14

Abstract: Abstract Dysregulation of microRNAs has a critical role in cancer progression. Here we identify an intronic microRNA, miR-135b that is upregulated in highly invasive non-small-cell lung cancer cells. Expression of miR-135b enhances cancer cell invasive and migratory abilities in vitro and promotes cancer metastasis in vivo, while specific inhibition of miR-135b by a miR-135b-specific molecular sponge and antagomirs suppresses cancer cell invasion, orthotopic lung tumour growth and metastasis in a mouse model. miR-135b targets multiple key components in the Hippo pathway, including LATS2, β-TrCP and NDR2, as well as LZTS1. Expression of miR-135b, LZTS1, LATS2 and nuclear TAZ predicts poor outcomes of non-small-cell lung cancer. We find that miR-135b is dually regulated by DNA demethylation and nuclear factor-kappaB signalling, implying that abnormal expression of miR-135b in cancer may result from inflammatory and epigenetic modulations. We conclude that miR-135b is an oncogenic microRNA and a potential therapeutic target for non-small-cell lung cancer.

Date: 2013
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DOI: 10.1038/ncomms2876

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