An influenza virus-inspired polymer system for the timed release of siRNA

Nghia P Truong, Wenyi Gu, Indira Prasadam, Zhongfan Jia, Ross Crawford, Yin Xiao and Michael J Monteiro ()
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Nghia P Truong: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Wenyi Gu: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Indira Prasadam: Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane Queensland 4059, Australia
Zhongfan Jia: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Ross Crawford: Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane Queensland 4059, Australia
Yin Xiao: Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane Queensland 4059, Australia
Michael J Monteiro: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract Small interfering RNA silences specific genes by interfering with mRNA translation, and acts to modulate or inhibit specific biological pathways; a therapy that holds great promise in the cure of many diseases. However, the naked small interfering RNA is susceptible to degradation by plasma and tissue nucleases and due to its negative charge unable to cross the cell membrane. Here we report a new polymer carrier designed to mimic the influenza virus escape mechanism from the endosome, followed by a timed release of the small interfering RNA in the cytosol through a self-catalyzed polymer degradation process. Our polymer changes to a negatively charged and non-toxic polymer after the release of small interfering RNA, presenting potential for multiple repeat doses and long-term treatment of diseases.

Date: 2013
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DOI: 10.1038/ncomms2905

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