B7-H5 costimulates human T cells via CD28H

Yuwen Zhu, Sheng Yao, Bettina P. Iliopoulou, Xue Han, Mathew M. Augustine, Haiying Xu, Ryan T. Phennicie, Sarah J. Flies, Megan Broadwater, William Ruff, Janis M. Taube, Linghua Zheng, Liqun Luo, Gefeng Zhu, Jianzhu Chen and Lieping Chen ()
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Yuwen Zhu: Yale University School of Medicine
Sheng Yao: Yale University School of Medicine
Bettina P. Iliopoulou: Massachusetts Institute of Technology
Xue Han: Yale University School of Medicine
Mathew M. Augustine: Johns Hopkins University School of Medicine
Haiying Xu: Johns Hopkins University School of Medicine
Ryan T. Phennicie: Massachusetts Institute of Technology
Sarah J. Flies: Johns Hopkins University School of Medicine
Megan Broadwater: Johns Hopkins University School of Medicine
William Ruff: Johns Hopkins University School of Medicine
Janis M. Taube: Johns Hopkins University School of Medicine
Linghua Zheng: Yale University School of Medicine
Liqun Luo: Yale University School of Medicine
Gefeng Zhu: Yale University School of Medicine
Jianzhu Chen: Massachusetts Institute of Technology
Lieping Chen: Yale University School of Medicine

Nature Communications, 2013, vol. 4, issue 1, 1-12

Abstract: Abstract The B7/CD28 family has profound modulatory effects in immune responses and constitutes an important target for the development of novel therapeutic drugs against human diseases. Here we describe a new CD28 homologue (CD28H) that has unique functions in the regulation of the human immune response and is absent in mice. CD28H is constitutively expressed on all naive T cells. Repetitive antigenic exposure, however, induces a complete loss of CD28H on many T cells, and CD28H negative T cells have a phenotype of terminal differentiation and senescence. After extensive screening in a receptor array, a B7-like molecule, B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H. B7-H5 is constitutively found in macrophages and could be induced on dendritic cells. The B7-H5/CD28H interaction selectively costimulates human T-cell growth and cytokine production via an AKT-dependent signalling cascade. Our study identifies a novel costimulatory pathway regulating human T-cell responses.

Date: 2013
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DOI: 10.1038/ncomms3043

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