α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors

S.C. Robins, I. Stewart, D.E. McNay, V. Taylor, C. Giachino, M. Goetz, J. Ninkovic, N. Briancon, E. Maratos-Flier, J.S. Flier, M.V. Kokoeva and M. Placzek ()
Additional contact information
S.C. Robins: University of Sheffield
I. Stewart: University of Sheffield
D.E. McNay: Beth Israel Deaconess Medical Centre, Diabetes and Metabolism, Centre for Life Sciences
V. Taylor: University of Basel
C. Giachino: University of Basel
M. Goetz: Institute for Stem Cell Research, Helmholtz Center
J. Ninkovic: Institute for Stem Cell Research, Helmholtz Center
N. Briancon: Beth Israel Deaconess Medical Centre, Diabetes and Metabolism, Centre for Life Sciences
E. Maratos-Flier: Beth Israel Deaconess Medical Centre, Diabetes and Metabolism, Centre for Life Sciences
J.S. Flier: Beth Israel Deaconess Medical Centre, Diabetes and Metabolism, Centre for Life Sciences
M.V. Kokoeva: McGill University, Royal Victoria Hospital
M. Placzek: University of Sheffield

Nature Communications, 2013, vol. 4, issue 1, 1-13

Abstract: Abstract Emerging evidence suggests that new cells, including neurons, can be generated within the adult hypothalamus, suggesting the existence of a local neural stem/progenitor cell niche. Here, we identify α-tanycytes as key components of a hypothalamic niche in the adult mouse. Long-term lineage tracing in vivo using a GLAST::CreERT2 conditional driver indicates that α-tanycytes are self-renewing cells that constitutively give rise to new tanycytes, astrocytes and sparse numbers of neurons. In vitro studies demonstrate that α-tanycytes, but not β-tanycytes or parenchymal cells, are neurospherogenic. Distinct subpopulations of α-tanycytes exist, amongst which only GFAP-positive dorsal α2-tanycytes possess stem-like neurospherogenic activity. Fgf-10 and Fgf-18 are expressed specifically within ventral tanycyte subpopulations; α-tanycytes require fibroblast growth factor signalling to maintain their proliferation ex vivo and elevated fibroblast growth factor levels lead to enhanced proliferation of α-tanycytes in vivo. Our results suggest that α-tanycytes form the critical component of a hypothalamic stem cell niche, and that local fibroblast growth factor signalling governs their proliferation.

Date: 2013
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DOI: 10.1038/ncomms3049

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