Spatiotemporally controlled induction of autophagy-mediated lysosome turnover

Yu-Hsien Hung, Lily Man-Wen Chen, Jin-Yi Yang and Wei Yuan Yang ()
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Yu-Hsien Hung: Institute of Biological Chemistry, Academia Sinica
Lily Man-Wen Chen: Institute of Biological Chemistry, Academia Sinica
Jin-Yi Yang: Institute of Biological Chemistry, Academia Sinica
Wei Yuan Yang: Institute of Biological Chemistry, Academia Sinica

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysosome impairing scheme that can be controlled spatially and temporally within a cell, we show that damaged lysosomes are selectively ubiquitinated, recruit autophagic proteins and are eventually incorporated into autolysosomes for degradation. We propose that autophagic removal of lysosomes, which we term lysophagy, is a surveillance mechanism that alleviates cells from the adverse effects of lysosomal damage. We envision our method to induce lysosomal damage will enable detailed molecular studies of the lysophagy pathway in the future.

Date: 2013
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DOI: 10.1038/ncomms3111

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