Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type

Gregor-Alexander Pilz, Atsunori Shitamukai, Isabel Reillo, Emilie Pacary, Julia Schwausch, Ronny Stahl, Jovica Ninkovic, Hugo J. Snippert, Hans Clevers, Leanne Godinho, Francois Guillemot, Victor Borrell, Fumio Matsuzaki and Magdalena Götz ()
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Gregor-Alexander Pilz: Institute of Stem Cell Research, Helmholtz Center Munich
Atsunori Shitamukai: RIKEN Center for Developmental Biology
Isabel Reillo: Developmental Neurobiology Unit, Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas—Universidad Miguel Hernández
Emilie Pacary: MRC National Institute for Medical Research
Julia Schwausch: Institute of Stem Cell Research, Helmholtz Center Munich
Ronny Stahl: Physiological Genomics, University of Munich
Jovica Ninkovic: Institute of Stem Cell Research, Helmholtz Center Munich
Hugo J. Snippert: Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Center Utrecht
Hans Clevers: Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Center Utrecht
Leanne Godinho: Institute of Stem Cell Research, Helmholtz Center Munich
Francois Guillemot: MRC National Institute for Medical Research
Victor Borrell: Developmental Neurobiology Unit, Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas—Universidad Miguel Hernández
Fumio Matsuzaki: RIKEN Center for Developmental Biology
Magdalena Götz: Institute of Stem Cell Research, Helmholtz Center Munich

Nature Communications, 2013, vol. 4, issue 1, 1-11

Abstract: Abstract The mechanisms governing the expansion of neuron number in specific brain regions are still poorly understood. Enlarged neuron numbers in different species are often anticipated by increased numbers of progenitors dividing in the subventricular zone. Here we present live imaging analysis of radial glial cells and their progeny in the ventral telencephalon, the region with the largest subventricular zone in the murine brain during neurogenesis. We observe lineage amplification by a new type of progenitor, including bipolar radial glial cells dividing at subapical positions and generating further proliferating progeny. The frequency of this new type of progenitor is increased not only in larger clones of the mouse lateral ganglionic eminence but also in cerebral cortices of gyrated species, and upon inducing gyrification in the murine cerebral cortex. This implies key roles of this new type of radial glia in ontogeny and phylogeny.

Date: 2013
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DOI: 10.1038/ncomms3125

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