SNAP-25 regulates spine formation through postsynaptic binding to p140Cap

Romana Tomasoni, Daniele Repetto, Raffaella Morini, Chiara Elia, Fabrizio Gardoni, Monica Di Luca, Emilia Turco, Paola Defilippi and Michela Matteoli ()
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Romana Tomasoni: University of Milan
Daniele Repetto: University of Turin
Raffaella Morini: University of Milan
Chiara Elia: University of Milan
Fabrizio Gardoni: University of Milan
Monica Di Luca: University of Milan
Emilia Turco: University of Turin
Paola Defilippi: University of Turin
Michela Matteoli: University of Milan

Nature Communications, 2013, vol. 4, issue 1, 1-13

Abstract: Abstract Synaptosomal-associated protein of 25 kDa (SNAP-25) is a member of the Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors (SNARE) protein family, required for exocytosis of synaptic vesicles and regulation of diverse ion channels. Here, we show that acute reduction of SNAP-25 expression leads to an immature phenotype of dendritic spines that are, consistently, less functional. Conversely, over-expression of SNAP-25 results in an increase in the density of mature, Postsynaptic Density protein 95 (PSD-95)-positive spines. The regulation of spine morphogenesis by SNAP-25 depends on the protein’s ability to bind both the plasma membrane and the adaptor protein p140Cap, a key protein regulating actin cytoskeleton and spine formation. We propose that SNAP-25 allows the organization of the molecular apparatus needed for spine formation by recruiting and stabilizing p140Cap.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3136

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DOI: 10.1038/ncomms3136

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