A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle

Kazuhiro Ikeda, Sachiko Shiba, Kuniko Horie-Inoue, Kunitoshi Shimokata and Satoshi Inoue ()
Additional contact information
Kazuhiro Ikeda: Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi
Sachiko Shiba: Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi
Kuniko Horie-Inoue: Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi
Kunitoshi Shimokata: Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi
Satoshi Inoue: Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi

Nature Communications, 2013, vol. 4, issue 1, 1-9

Abstract: Abstract The mitochondrial respiratory chain is essential for oxidative phosphorylation and comprises multiple complexes, including cytochrome c oxidase, assembled in macromolecular supercomplexes. Little is known about factors that contribute to supercomplex organization. Here we identify COX7RP as a factor that promotes supercomplex assembly. Cox7rp-knockout mice exhibit decreased muscular activity and heat production failure in the cold due to reduced COX activity. In contrast, COX7RP-transgenic mice exhibit increased exercise performance with increased cytochrome c oxidase activity. Two-dimensional blue native electrophoresis reveals that COX7RP is a key molecule that promotes assembly of the III2/IVn supercomplex with complex I. Our study identified COX7RP as a protein that functions in I/III2/IVn supercomplex assembly and is required for full activity of mitochondrial respiration.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms3147 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3147

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms3147

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().