Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota

Yongfei Hu, Xi Yang, Junjie Qin, Na Lu, Gong Cheng, Na Wu, Yuanlong Pan, Jing Li, Liying Zhu, Xin Wang, Zhiqi Meng, Fangqing Zhao, Di Liu, Juncai Ma, Nan Qin, Chunsheng Xiang, Yonghong Xiao, Lanjuan Li, Huanming Yang, Jian Wang, Ruifu Yang, George F. Gao, Jun Wang and Baoli Zhu ()
Additional contact information
Yongfei Hu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Xi Yang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Junjie Qin: BGI-Shenzhen
Na Lu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Gong Cheng: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Na Wu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Yuanlong Pan: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Jing Li: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Liying Zhu: State Key Laboratory of Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences
Xin Wang: State Key Laboratory of Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences
Zhiqi Meng: State Key Laboratory of Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences
Fangqing Zhao: Computational Genomics Laboratory, Beijing Institutes of Life Science, Chinese Academy of Sciences
Di Liu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Juncai Ma: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Nan Qin: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University
Chunsheng Xiang: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University
Yonghong Xiao: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University
Lanjuan Li: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University
Huanming Yang: BGI-Shenzhen
Jian Wang: BGI-Shenzhen
Ruifu Yang: State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology
George F. Gao: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Jun Wang: BGI-Shenzhen
Baoli Zhu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota.

Date: 2013
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DOI: 10.1038/ncomms3151

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