Structural modulation of gut microbiota in life-long calorie-restricted mice

Chenhong Zhang, Shoufeng Li, Liu Yang, Ping Huang, Wenjun Li, Shengyue Wang, Guoping Zhao, Menghui Zhang, Xiaoyan Pang, Zhen Yan, Yong Liu () and Liping Zhao ()
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Chenhong Zhang: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Shoufeng Li: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences
Liu Yang: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences
Ping Huang: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences
Wenjun Li: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences
Shengyue Wang: Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Centre
Guoping Zhao: Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Centre
Menghui Zhang: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Xiaoyan Pang: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
Zhen Yan: University of Virginia
Yong Liu: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences
Liping Zhao: State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract Calorie restriction has been regarded as the only experimental regimen that can effectively lengthen lifespan in various animal models, but the actual mechanism remains controversial. The gut microbiota has been shown to have a pivotal role in host health, and its structure is mostly shaped by diet. Here we show that life-long calorie restriction on both high-fat or low-fat diet, but not voluntary exercise, significantly changes the overall structure of the gut microbiota of C57BL/6 J mice. Calorie restriction enriches phylotypes positively correlated with lifespan, for example, the genus Lactobacillus on low-fat diet, and reduces phylotypes negatively correlated with lifespan. These calorie restriction-induced changes in the gut microbiota are concomitant with significantly reduced serum levels of lipopolysaccharide-binding protein, suggesting that animals under calorie restriction can establish a structurally balanced architecture of gut microbiota that may exert a health benefit to the host via reduction of antigen load from the gut.

Date: 2013
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DOI: 10.1038/ncomms3163

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