Rare-earth-doped biological composites as in vivo shortwave infrared reporters

D. J. Naczynski, M. C. Tan, M. Zevon, B. Wall, J. Kohl, A. Kulesa, Song Chen, C. M. Roth, R. E. Riman and P. V. Moghe ()
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D. J. Naczynski: Biomedical Engineering, Chemical and Biochemical Engineering
M. C. Tan: Materials Science and Engineering, Rutgers University
M. Zevon: Biomedical Engineering, Chemical and Biochemical Engineering
B. Wall: Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University
J. Kohl: Materials Science and Engineering, Rutgers University
A. Kulesa: Biomedical Engineering, Chemical and Biochemical Engineering
C. M. Roth: Biomedical Engineering, Chemical and Biochemical Engineering
R. E. Riman: Materials Science and Engineering, Rutgers University
P. V. Moghe: Biomedical Engineering, Chemical and Biochemical Engineering

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract The extension of in vivo optical imaging for disease screening and image-guided surgical interventions requires brightly emitting, tissue-specific materials that optically transmit through living tissue and can be imaged with portable systems that display data in real-time. Recent work suggests that a new window across the short-wavelength infrared region can improve in vivo imaging sensitivity over near infrared light. Here we report on the first evidence of multispectral, real-time short-wavelength infrared imaging offering anatomical resolution using brightly emitting rare-earth nanomaterials and demonstrate their applicability toward disease-targeted imaging. Inorganic-protein nanocomposites of rare-earth nanomaterials with human serum albumin facilitated systemic biodistribution of the rare-earth nanomaterials resulting in the increased accumulation and retention in tumour tissue that was visualized by the localized enhancement of infrared signal intensity. Our findings lay the groundwork for a new generation of versatile, biomedical nanomaterials that can advance disease monitoring based on a pioneering infrared imaging technique.

Date: 2013
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DOI: 10.1038/ncomms3199

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