Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii

Inge Seim, Xiaodong Fang, Zhiqiang Xiong, Alexey V. Lobanov, Zhiyong Huang, Siming Ma, Yue Feng, Anton A. Turanov, Yabing Zhu, Tobias L. Lenz, Maxim V. Gerashchenko, Dingding Fan, Sun Hee Yim, Xiaoming Yao, Daniel Jordan, Yingqi Xiong, Yong Ma, Andrey N. Lyapunov, Guanxing Chen, Oksana I. Kulakova, Yudong Sun, Sang-Goo Lee, Roderick T. Bronson, Alexey A. Moskalev, Shamil R. Sunyaev, Guojie Zhang, Anders Krogh, Jun Wang () and Vadim N. Gladyshev ()
Additional contact information
Inge Seim: Brigham and Women’s Hospital, Harvard Medical School
Xiaodong Fang: BGI-Shenzhen
Zhiqiang Xiong: BGI-Shenzhen
Alexey V. Lobanov: Brigham and Women’s Hospital, Harvard Medical School
Zhiyong Huang: BGI-Shenzhen
Siming Ma: Brigham and Women’s Hospital, Harvard Medical School
Yue Feng: BGI-Shenzhen
Anton A. Turanov: Brigham and Women’s Hospital, Harvard Medical School
Yabing Zhu: BGI-Shenzhen
Tobias L. Lenz: Brigham and Women’s Hospital, Harvard Medical School
Maxim V. Gerashchenko: Brigham and Women’s Hospital, Harvard Medical School
Dingding Fan: BGI-Shenzhen
Sun Hee Yim: Brigham and Women’s Hospital, Harvard Medical School
Xiaoming Yao: BGI-Shenzhen
Daniel Jordan: Brigham and Women’s Hospital, Harvard Medical School
Yingqi Xiong: BGI-Shenzhen
Yong Ma: BGI-Shenzhen
Andrey N. Lyapunov: Kirov State Center for Distance Education of Children
Guanxing Chen: BGI-Shenzhen
Oksana I. Kulakova: Institute of Biology, Komi Science Center, Russian Academy of Sciences
Yudong Sun: BGI-Shenzhen
Sang-Goo Lee: Ewha Womans University
Roderick T. Bronson: Rodent Histopathology Laboratory, Harvard Medical School
Alexey A. Moskalev: Institute of Biology, Komi Science Center, Russian Academy of Sciences
Shamil R. Sunyaev: Brigham and Women’s Hospital, Harvard Medical School
Guojie Zhang: BGI-Shenzhen
Anders Krogh: Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
Jun Wang: BGI-Shenzhen
Vadim N. Gladyshev: Brigham and Women’s Hospital, Harvard Medical School

Nature Communications, 2013, vol. 4, issue 1, 1-8

Abstract: Abstract Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt’s bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4–8 g adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity. Here we report sequencing and analysis of the Brandt’s bat genome and transcriptome, which suggest adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction and visual function. Unique sequence changes in growth hormone and insulin-like growth factor 1 receptors are also observed. The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt’s bat.

Date: 2013
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DOI: 10.1038/ncomms3212

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