A poly(A)-specific ribonuclease directly regulates the poly(A) status of mitochondrial mRNA in Arabidopsis

Takashi Hirayama (), Takakazu Matsuura, Sho Ushiyama, Mari Narusaka, Yukio Kurihara, Michiko Yasuda, Misato Ohtani, Motoaki Seki, Taku Demura, Hideo Nakashita, Yoshihiro Narusaka and Shimpei Hayashi
Additional contact information
Takashi Hirayama: Institute of Plant Science and Resources, Okayama University
Takakazu Matsuura: Institute of Plant Science and Resources, Okayama University
Sho Ushiyama: Graduate School of Nanobioscience, Yokohama City University
Mari Narusaka: Research Institute for Biological Sciences Okayama
Yukio Kurihara: Plant Science Center, RIKEN
Michiko Yasuda: RIKEN Innovation Center
Misato Ohtani: Biomass Engineering Program, RIKEN
Motoaki Seki: Plant Science Center, RIKEN
Taku Demura: Biomass Engineering Program, RIKEN
Hideo Nakashita: RIKEN Innovation Center
Yoshihiro Narusaka: Research Institute for Biological Sciences Okayama
Shimpei Hayashi: Graduate School of Nanobioscience, Yokohama City University

Nature Communications, 2013, vol. 4, issue 1, 1-9

Abstract: Abstract Coordination of gene expression in the organelles and the nucleus is important for eukaryotic cell function. Transcriptional and post-transcriptional gene regulation in mitochondria remains incompletely understood in most eukaryotes, including plants. Here we show that poly(A)-specific ribonuclease, which influences the poly(A) status of cytoplasmic mRNA in many eukaryotes, directly regulates the poly(A) tract of mitochondrial mRNA in conjunction with a bacterial-type poly(A) polymerase, AGS1, in Arabidopsis. An Arabidopsis poly(A)-specific ribonuclease-deficient mutant, ahg2-1, accumulates polyadenylated mitochondrial mRNA and shows defects in mitochondrial protein complex levels. Mutations of AGS1 suppress the ahg2-1 phenotype. Mitochondrial localizations of AHG2 and AGS1 are required for their functions in the regulation of the poly(A) tract of mitochondrial mRNA. Our findings suggest that AHG2 and AGS1 constitute a regulatory system that controls mitochondrial mRNA poly(A) status in Arabidopsis.

Date: 2013
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms3247 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3247

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms3247

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().