Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging

Zhenghuan Zhao, Zijian Zhou, Jianfeng Bao, Zhenyu Wang, Juan Hu, Xiaoqin Chi, Kaiyuan Ni, Ruifang Wang, Xiaoyuan Chen, Zhong Chen and Jinhao Gao ()
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Zhenghuan Zhao: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University
Zijian Zhou: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University
Jianfeng Bao: Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University
Zhenyu Wang: Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University
Juan Hu: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University
Xiaoqin Chi: Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital, Xiamen University
Kaiyuan Ni: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University
Ruifang Wang: Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University
Xiaoyuan Chen: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Zhong Chen: Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University
Jinhao Gao: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract Spherical superparamagnetic iron oxide nanoparticles have been developed as T2-negative contrast agents for magnetic resonance imaging in clinical use because of their biocompatibility and ease of synthesis; however, they exhibit relatively low transverse relaxivity. Here we report a new strategy to achieve high transverse relaxivity by controlling the morphology of iron oxide nanoparticles. We successfully fabricate size-controllable octapod iron oxide nanoparticles by introducing chloride anions. The octapod iron oxide nanoparticles (edge length of 30 nm) exhibit an ultrahigh transverse relaxivity value (679.3±30 mM−1 s−1), indicating that these octapod iron oxide nanoparticles are much more effective T2 contrast agents for in vivo imaging and small tumour detection in comparison with conventional iron oxide nanoparticles, which holds great promise for highly sensitive, early stage and accurate detection of cancer in the clinic.

Date: 2013
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DOI: 10.1038/ncomms3266

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