DNA-directed self-assembly of shape-controlled hydrogels

Hao Qi, Majid Ghodousi, Yanan Du, Casey Grun, Hojae Bae, Peng Yin () and Ali Khademhosseini ()
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Hao Qi: Wyss Institute for Biologically Inspired Engineering, Harvard University
Majid Ghodousi: Wyss Institute for Biologically Inspired Engineering, Harvard University
Yanan Du: Wyss Institute for Biologically Inspired Engineering, Harvard University
Casey Grun: Wyss Institute for Biologically Inspired Engineering, Harvard University
Hojae Bae: Wyss Institute for Biologically Inspired Engineering, Harvard University
Peng Yin: Wyss Institute for Biologically Inspired Engineering, Harvard University
Ali Khademhosseini: Wyss Institute for Biologically Inspired Engineering, Harvard University

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract Using DNA as programmable, sequence-specific ‘glues’, shape-controlled hydrogel units are self-assembled into prescribed structures. Here we report that aggregates are produced using hydrogel cubes with edge lengths ranging from 30 μm to 1 mm, demonstrating assembly across scales. In a simple one-pot agitation reaction, 25 dimers are constructed in parallel from 50 distinct hydrogel cube species, demonstrating highly multiplexed assembly. Using hydrogel cuboids displaying face-specific DNA glues, diverse structures are achieved in aqueous and in interfacial agitation systems. These include dimers, extended chains and open network structures in an aqueous system, and dimers, chains of fixed length, T-junctions and square shapes in the interfacial system, demonstrating the versatility of the assembly system.

Date: 2013
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DOI: 10.1038/ncomms3275

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