In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles

Luo Gu, David J. Hall, Zhengtao Qin, Emily Anglin, Jinmyoung Joo, David J. Mooney, Stephen B. Howell and Michael J. Sailor ()
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Luo Gu: University of California, San Diego
David J. Hall: University of California, San Diego
Zhengtao Qin: University of California, San Diego
Emily Anglin: University of California, San Diego
Jinmyoung Joo: University of California, San Diego
David J. Mooney: School of Engineering and Applied Sciences, Harvard University
Stephen B. Howell: Moores Cancer Center, University of California, San Diego
Michael J. Sailor: University of California, San Diego

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract Fluorescence imaging is one of the most versatile and widely used visualization methods in biomedical research. However, tissue autofluorescence is a major obstacle confounding interpretation of in vivo fluorescence images. The unusually long emission lifetime (5–13 μs) of photoluminescent porous silicon nanoparticles can allow the time-gated imaging of tissues in vivo, completely eliminating shorter-lived ( 50-fold in vitro and by >20-fold in vivo when imaging porous silicon nanoparticles. Time-gated imaging of porous silicon nanoparticles accumulated in a human ovarian cancer xenograft following intravenous injection is demonstrated in a live mouse. The potential for multiplexing of images in the time domain by using separate porous silicon nanoparticles engineered with different excited state lifetimes is discussed.

Date: 2013
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DOI: 10.1038/ncomms3326

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