Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish

Julien Prudent, Nikolay Popgeorgiev, Benjamin Bonneau, Julien Thibaut, Rudy Gadet, Jonathan Lopez, Philippe Gonzalo, Ruth Rimokh, Stephen Manon, Corinne Houart, Philippe Herbomel, Abdel Aouacheria and Germain Gillet ()
Additional contact information
Julien Prudent: Université de Lyon, Centre de recherche en cancérologie de Lyon, U1052 INSERM, UMS 3453 CNRS, Université Lyon I, Centre Léon Bérard, 28 rue Laennec
Nikolay Popgeorgiev: Université de Lyon, Centre de recherche en cancérologie de Lyon, U1052 INSERM, UMS 3453 CNRS, Université Lyon I, Centre Léon Bérard, 28 rue Laennec
Benjamin Bonneau: Université de Lyon, Centre de recherche en cancérologie de Lyon, U1052 INSERM, UMS 3453 CNRS, Université Lyon I, Centre Léon Bérard, 28 rue Laennec
Julien Thibaut: Université de Lyon, Centre de recherche en cancérologie de Lyon, U1052 INSERM, UMS 3453 CNRS, Université Lyon I, Centre Léon Bérard, 28 rue Laennec
Rudy Gadet: Université de Lyon, Centre de recherche en cancérologie de Lyon, U1052 INSERM, UMS 3453 CNRS, Université Lyon I, Centre Léon Bérard, 28 rue Laennec
Jonathan Lopez: Université de Lyon, Centre de recherche en cancérologie de Lyon, U1052 INSERM, UMS 3453 CNRS, Université Lyon I, Centre Léon Bérard, 28 rue Laennec
Philippe Gonzalo: Université de Lyon, Centre de recherche en cancérologie de Lyon, U1052 INSERM, UMS 3453 CNRS, Université Lyon I, Centre Léon Bérard, 28 rue Laennec
Ruth Rimokh: Université de Lyon, Centre de recherche en cancérologie de Lyon, U1052 INSERM, UMS 3453 CNRS, Université Lyon I, Centre Léon Bérard, 28 rue Laennec
Stephen Manon: Université de Bordeaux, Institut de génétique et biochimie cellulaires, UMR 5095 CNRS, 1 rue Camille Saint-Saëns
Corinne Houart: MRC Centre for Developmental Neurobiology, King’s college, University of London, NHH, Guy’s Campus
Philippe Herbomel: CNRS-URA 2578, Institut Pasteur, 25 rue du Dr Roux
Abdel Aouacheria: Laboratoire de Biologie Moléculaire de la Cellule, Ecole Normale Supérieure de Lyon, UMR 5239 CNRS–UCBL–ENS Lyon, Université de Lyon, SFR BioSciences Gerland, Lyon Sud (UMS3444/US8), 46 Allée d’Italie
Germain Gillet: Université de Lyon, Centre de recherche en cancérologie de Lyon, U1052 INSERM, UMS 3453 CNRS, Université Lyon I, Centre Léon Bérard, 28 rue Laennec

Nature Communications, 2013, vol. 4, issue 1, 1-15

Abstract: Abstract Bcl-2 proteins are acknowledged as key regulators of programmed cell death. However, increasing data suggest additional roles, including regulation of the cell cycle, metabolism and cytoskeletal dynamics. Here we report the discovery and characterization of a new Bcl-2-related multidomain apoptosis accelerator, Bcl-wav, found in fish and frogs. Genetic and molecular studies in zebrafish indicate that Bcl-wav and the recently identified mitochondrial calcium uniporter (MCU) contribute to the formation of the notochord axis by controlling blastomere convergence and extension movements during gastrulation. Furthermore, we found that Bcl-wav controls intracellular Ca2+ trafficking by acting on the mitochondrial voltage-dependent anion channel, and possibly on MCU, with direct consequences on actin microfilament dynamics and blastomere migration guidance. Thus, from an evolutionary point of view, the original function of Bcl-2 proteins might have been to contribute in controlling the global positioning system of blastomeres during gastrulation, a critical step in metazoan development.

Date: 2013
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms3330 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3330

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms3330

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().