p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1

Bei Wang, Dandan Niu, Liyun Lai and Ee Chee Ren ()
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Bei Wang: Singapore Immunology Network, A*STAR
Dandan Niu: Singapore Immunology Network, A*STAR
Liyun Lai: Singapore Immunology Network, A*STAR
Ee Chee Ren: Singapore Immunology Network, A*STAR

Nature Communications, 2013, vol. 4, issue 1, 1-11

Abstract: Abstract The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell line HCT116, which lacks p53 exhibits significantly lower major histocompatibility complex I expression than its wild-type counterpart. Using a combination of chromatin immunoprecipitation sequencing and gene expression analysis, we demonstrate that p53 upregulates expression of endoplasmic reticulum aminopeptidase 1 by binding to its cognate response element in the ERAP1 gene. Silencing of p53 decreases endoplasmic reticulum aminopeptidase 1 protein levels and therefore major histocompatibility complex I expression. We further show that this mechanism operates in A549 cells infected with H1N1 influenza virus, in which H1N1 activates p53, leading to endoplasmic reticulum aminopeptidase 1 upregulation and a corresponding increase in major histocompatibility complex I expression. Our study suggests a previously unrecognized link between p53 function and the immunosurveillance of cancer and infection.

Date: 2013
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DOI: 10.1038/ncomms3359

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