Human gut microbiota community structures in urban and rural populations in Russia

Alexander V. Tyakht (), Elena S. Kostryukova, Anna S. Popenko, Maxim S. Belenikin, Alexander V. Pavlenko, Andrey K. Larin, Irina Y. Karpova, Oksana V. Selezneva, Tatyana A. Semashko, Elena A. Ospanova, Vladislav V. Babenko, Igor V. Maev, Sergey V. Cheremushkin, Yuriy A. Kucheryavyy, Petr L. Shcherbakov, Vladimir B. Grinevich, Oleg I. Efimov, Evgenii I. Sas, Rustam A. Abdulkhakov, Sayar R. Abdulkhakov, Elena A. Lyalyukova, Maria A. Livzan, Valentin V. Vlassov, Renad Z. Sagdeev, Vladislav V. Tsukanov, Marina F. Osipenko, Irina V. Kozlova, Alexander V. Tkachev, Valery I. Sergienko, Dmitry G. Alexeev and Vadim M. Govorun
Additional contact information
Alexander V. Tyakht: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Elena S. Kostryukova: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Anna S. Popenko: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Maxim S. Belenikin: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Alexander V. Pavlenko: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Andrey K. Larin: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Irina Y. Karpova: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Oksana V. Selezneva: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Tatyana A. Semashko: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Elena A. Ospanova: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Vladislav V. Babenko: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Igor V. Maev: Moscow State University of Medicine and Dentistry, Delegatskaya 20-1, Moscow 127473, Russia
Sergey V. Cheremushkin: Moscow State University of Medicine and Dentistry, Delegatskaya 20-1, Moscow 127473, Russia
Yuriy A. Kucheryavyy: Moscow State University of Medicine and Dentistry, Delegatskaya 20-1, Moscow 127473, Russia
Petr L. Shcherbakov: Central Scientific Institute of Gastroenterology, Shosse Entuziastov 86, Moscow 111123, Russia
Vladimir B. Grinevich: Kirov Military Medical Academy, Lebedeva 6, Saint Petersburg 194175, Russia
Oleg I. Efimov: Kirov Military Medical Academy, Lebedeva 6, Saint Petersburg 194175, Russia
Evgenii I. Sas: Kirov Military Medical Academy, Lebedeva 6, Saint Petersburg 194175, Russia
Rustam A. Abdulkhakov: Kazan’ State Medical University, Butlerova 49, Kazan’ 420012, Russia
Sayar R. Abdulkhakov: Kazan' (Volga Region) Federal University, Kremlyovskaya 18, Kazan' 420008, Russia
Elena A. Lyalyukova: Omsk State Medical Academy, Lenina 12, Omsk 644043, Russia
Maria A. Livzan: Omsk State Medical Academy, Lenina 12, Omsk 644043, Russia
Valentin V. Vlassov: Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Prospekt Akademika Lavrent'eva 8, Novosibirsk 630090, Russia
Renad Z. Sagdeev: International Tomography Center of the Siberian Branch of the Russian Academy of Sciences, Institutskaya 3A, Novosibirsk 630090, Russia
Vladislav V. Tsukanov: Scientific Research Institute of Medical Problems of the North, Partizana Zhelezniaka 3G, Krasnoyarsk 660022, Russia
Marina F. Osipenko: Novosibirsk State Medical University, Krasny Prospect 52, Novosibirsk 630091, Russia
Irina V. Kozlova: Saratov State Medical University, Bolshaya Kazachia 112, Saratov 410012, Russia
Alexander V. Tkachev: Rostov State Medical University, Suvorova 118/50, Rostov-on-Don 344022, Russia
Valery I. Sergienko: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Dmitry G. Alexeev: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
Vadim M. Govorun: Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia

Nature Communications, 2013, vol. 4, issue 1, 1-9

Abstract: Abstract The microbial community of the human gut has a crucial role in sustaining host homeostasis. High-throughput DNA sequencing has delineated the structural and functional configurations of gut metagenomes in world populations. The microbiota of the Russian population is of particular interest to researchers, because Russia encompasses a uniquely wide range of environmental conditions and ethnogeographical cohorts. Here we conduct a shotgun metagenomic analysis of gut microbiota samples from 96 healthy Russian adult subjects, which reveals novel microbial community structures. The communities from several rural regions display similarities within each region and are dominated by the bacterial taxa associated with the healthy gut. Functional analysis shows that the metabolic pathways exhibiting differential abundance in the novel types are primarily associated with the trade-off between the Bacteroidetes and Firmicutes phyla. The specific signatures of the Russian gut microbiota are likely linked to the host diet, cultural habits and socioeconomic status.

Date: 2013
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DOI: 10.1038/ncomms3469

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