Auxin-Binding Protein 1 is a negative regulator of the SCFTIR1/AFB pathway

Alexandre Tromas, Sébastien Paque, Vérène Stierlé, Anne-Laure Quettier, Philippe Muller, Esther Lechner, Pascal Genschik and Catherine Perrot-Rechenmann ()
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Alexandre Tromas: Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences
Sébastien Paque: Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences
Vérène Stierlé: Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences
Anne-Laure Quettier: Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences
Philippe Muller: Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences
Esther Lechner: Institut de Biologie Moléculaire des Plantes (IBMP), UPR2357 Centre National de la Recherche Scientifique
Pascal Genschik: Institut de Biologie Moléculaire des Plantes (IBMP), UPR2357 Centre National de la Recherche Scientifique
Catherine Perrot-Rechenmann: Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences

Nature Communications, 2013, vol. 4, issue 1, 1-9

Abstract: Abstract Auxin is a major plant hormone that controls most aspects of plant growth and development. Auxin is perceived by two distinct classes of receptors: transport inhibitor response 1 (TIR1, or auxin-related F-box (AFB)) and auxin/indole-3-acetic acid (AUX/IAA) coreceptors, that control transcriptional responses to auxin, and the auxin-binding protein 1 (ABP1), that controls a wide variety of growth and developmental processes. To date, the mode of action of ABP1 is still poorly understood and its functional interaction with TIR1/AFB–AUX/IAA coreceptors remains elusive. Here we combine genetic and biochemical approaches to gain insight into the integration of these two pathways. We find that ABP1 is genetically upstream of TIR1/AFBs; ABP1 knockdown leads to an enhanced degradation of AUX/IAA repressors, independently of its effects on endocytosis, through the SCFTIR1/AFB E3 ubiquitin ligase pathway. Combining positive and negative regulation of SCF ubiquitin-dependent pathways might be a common mechanism conferring tight control of hormone-mediated responses.

Date: 2013
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DOI: 10.1038/ncomms3496

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