Functional salivary gland regeneration by transplantation of a bioengineered organ germ

Miho Ogawa, Masamitsu Oshima, Aya Imamura, Yurie Sekine, Kentaro Ishida, Kentaro Yamashita, Kei Nakajima, Masatoshi Hirayama, Tetsuhiko Tachikawa and Takashi Tsuji ()
Additional contact information
Miho Ogawa: Research Institute for Science and Technology, Tokyo University of Science
Masamitsu Oshima: Research Institute for Science and Technology, Tokyo University of Science
Aya Imamura: Graduate School of Industrial Science and Technology, Tokyo University of Science
Yurie Sekine: Graduate School of Industrial Science and Technology, Tokyo University of Science
Kentaro Ishida: Research Institute for Science and Technology, Tokyo University of Science
Kentaro Yamashita: Graduate School of Industrial Science and Technology, Tokyo University of Science
Kei Nakajima: Tokyo Dental College
Masatoshi Hirayama: Keio University School of Medicine
Tetsuhiko Tachikawa: Showa University School of Dentistry
Takashi Tsuji: Research Institute for Science and Technology, Tokyo University of Science

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiation therapy for head cancer, Sjögren’s syndrome or aging, and can cause a variety of critical oral health issues, including dental decay, bacterial infection, mastication dysfunction, swallowing dysfunction and reduced quality of life. Here we demonstrate the full functional regeneration of a salivary gland that reproduces the morphogenesis induced by reciprocal epithelial and mesenchymal interactions through the orthotopic transplantation of a bioengineered salivary gland germ as a regenerative organ replacement therapy. The bioengineered germ develops into a mature gland through acinar formations with a myoepithelium and innervation. The bioengineered submandibular gland produces saliva in response to the administration of pilocarpine and gustatory stimulation by citrate, protects against oral bacterial infection and restores normal swallowing in a salivary gland-defective mouse model. This study thus provides a proof-of-concept for bioengineered salivary gland regeneration as a potential treatment of xerostomia.

Date: 2013
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms3498 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3498

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms3498

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().