Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma

Matthew Frampton, Miguel Inacio da Silva Filho, Peter Broderick, Hauke Thomsen, Asta Försti, Jayaram Vijayakrishnan, Rosie Cooke, Victor Enciso-Mora, Per Hoffmann, Markus M. Nöthen, Amy Lloyd, Amy Holroyd, Lewin Eisele, Karl-Heinz Jöckel, Sabine Ponader, Elke Pogge von Strandmann, Tracy Lightfoot, Eve Roman, Annette Lake, Dorothy Montgomery, Ruth F. Jarrett, Anthony J. Swerdlow, Andreas Engert, Kari Hemminki and Richard S. Houlston ()
Additional contact information
Matthew Frampton: Institute of Cancer Research
Miguel Inacio da Silva Filho: German Cancer Research Centre
Peter Broderick: Institute of Cancer Research
Hauke Thomsen: German Cancer Research Centre
Asta Försti: German Cancer Research Centre
Jayaram Vijayakrishnan: Institute of Cancer Research
Rosie Cooke: Institute of Cancer Research
Victor Enciso-Mora: Institute of Cancer Research
Per Hoffmann: Institute of Human Genetics, University of Bonn
Markus M. Nöthen: Institute of Human Genetics, University of Bonn
Amy Lloyd: Institute of Cancer Research
Amy Holroyd: Institute of Cancer Research
Lewin Eisele: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg–Essen
Karl-Heinz Jöckel: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg–Essen
Sabine Ponader: University Hospital of Cologne
Elke Pogge von Strandmann: University Hospital of Cologne
Tracy Lightfoot: Epidemiology and Cancer Statistics Group, University of York
Eve Roman: Epidemiology and Cancer Statistics Group, University of York
Annette Lake: MRC University of Glasgow Centre for Virus Research
Dorothy Montgomery: MRC University of Glasgow Centre for Virus Research
Ruth F. Jarrett: MRC University of Glasgow Centre for Virus Research
Anthony J. Swerdlow: Institute of Cancer Research
Andreas Engert: University Hospital of Cologne
Kari Hemminki: German Cancer Research Centre
Richard S. Houlston: Institute of Cancer Research

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10−12, odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10−9, OR=1.21). rs3806624 localizes 5′ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

Date: 2013
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DOI: 10.1038/ncomms3549

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