DNA-based highly tunable particle focuser

Kyowon Kang, Sung Sik Lee, Kyu Hyun, Seong Jae Lee and Ju Min Kim ()
Additional contact information
Kyowon Kang: Ajou University
Sung Sik Lee: Institute of Biochemistry, ETH Zurich
Kyu Hyun: School of Chemical and Biomolecular Engineering, Pusan National University
Seong Jae Lee: The University of Suwon, Hwaseong
Ju Min Kim: Ajou University

Nature Communications, 2013, vol. 4, issue 1, 1-8

Abstract: Abstract DNA is distinguished by both long length and structural rigidity. Classical polymer theories predict that DNA enhances the non-Newtonian elastic properties of its dilute solution more significantly than common synthetic flexible polymers because of its larger size and longer relaxation time. Here we exploit this property to report that under Poiseuille microflow, rigid spherical particles laterally migrate and form a tightly focused stream in an extremely dilute DNA solution (0.0005 (w/v)%). By the use of the DNA solution, we achieve highly efficient focusing (>99.5%) over an unprecedented wide range of flow rates (ratio of maximum to minimum flow rates ~400). This highly tunable particle-focusing technique can be used in the design of cost-effective portable flow cytometers, high-throughput cell analysis and also for cell sorting by size. We demonstrate that DNA is an efficient elasticity enhancer, which originates from its unique structural properties.

Date: 2013
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms3567 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3567

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms3567

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().