Circuit reactivation dynamically regulates synaptic plasticity in neocortex

Peter B. Kruskal, Lucy Li and Jason N MacLean ()
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Peter B. Kruskal: Committee on Computational Neuroscience, University of Chicago
Lucy Li: University of Chicago
Jason N MacLean: Committee on Computational Neuroscience, University of Chicago

Nature Communications, 2013, vol. 4, issue 1, 1-11

Abstract: Abstract Circuit reactivations involve a stereotyped sequence of neuronal firing and have been behaviourally linked to memory consolidation. Here we use multiphoton imaging and patch-clamp recording, and observe sparse and stereotyped circuit reactivations that correspond to UP states within active neurons. To evaluate the effect of the circuit on synaptic plasticity, we trigger a single spike-timing-dependent plasticity (STDP) pairing once per circuit reactivation. The pairings reliably fall within a particular epoch of the circuit sequence and result in long-term potentiation. During reactivation, the amplitude of plasticity significantly correlates with the preceding 20–25 ms of membrane depolarization rather than the depolarization at the time of pairing. This circuit-dependent plasticity provides a natural constraint on synaptic potentiation, regulating the inherent instability of STDP in an assembly phase-sequence model. Subthreshold voltage during endogenous circuit reactivations provides a critical informative context for plasticity and facilitates the stable consolidation of a spatiotemporal sequence.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3574

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DOI: 10.1038/ncomms3574

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