Molecular mechanism of strigolactone perception by DWARF14

Hidemitsu Nakamura, You-Lin Xue, Takuya Miyakawa, Feng Hou, Hui-Min Qin, Kosuke Fukui, Xuan Shi, Emi Ito, Shinsaku Ito, Seung-Hyun Park, Yumiko Miyauchi, Atsuko Asano, Naoya Totsuka, Takashi Ueda, Masaru Tanokura and Tadao Asami ()
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Hidemitsu Nakamura: Graduate School of Agricultural and Life Sciences, The University of Tokyo
You-Lin Xue: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Takuya Miyakawa: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Feng Hou: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Hui-Min Qin: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Kosuke Fukui: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Xuan Shi: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Emi Ito: Graduate School of Science, The University of Tokyo
Shinsaku Ito: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Seung-Hyun Park: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Yumiko Miyauchi: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Atsuko Asano: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Naoya Totsuka: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Takashi Ueda: Graduate School of Science, The University of Tokyo
Masaru Tanokura: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Tadao Asami: Graduate School of Agricultural and Life Sciences, The University of Tokyo

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract Strigolactones (SLs) are phytohormones that inhibit shoot branching and function in the rhizospheric communication with symbiotic fungi and parasitic weeds. An α/β-hydrolase protein, DWARF14 (D14), has been recognized to be an essential component of plant SL signalling, although its precise function remains unknown. Here we present the SL-dependent interaction of D14 with a gibberellin signalling repressor SLR1 and a possible mechanism of phytohormone perception in D14-mediated SL signalling. D14 functions as a cleavage enzyme of SLs, and the cleavage reaction induces the interaction with SLR1. The crystal structure of D14 shows that 5-hydroxy-3-methylbutenolide (D-OH), which is a reaction product of SLs, is trapped in the catalytic cavity of D14 to form an altered surface. The D14 residues recognizing D-OH are critical for the SL-dependent D14−SLR1 interaction. These results provide new insight into crosstalk between gibberellin and SL signalling pathways.

Date: 2013
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DOI: 10.1038/ncomms3613

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