Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans

Kuniko Takagi, Romain Legrand, Akihiro Asakawa, Haruka Amitani, Marie François, Naouel Tennoune, Moïse Coëffier, Sophie Claeyssens, Jean-Claude do Rego, Pierre Déchelotte, Akio Inui and Sergueï O. Fetissov ()
Additional contact information
Kuniko Takagi: Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Romain Legrand: Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Akihiro Asakawa: Kagoshima University Graduate School of Medical and Dental Sciences
Haruka Amitani: Kagoshima University Graduate School of Medical and Dental Sciences
Marie François: Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Naouel Tennoune: Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Moïse Coëffier: Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Sophie Claeyssens: Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Jean-Claude do Rego: Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University
Pierre Déchelotte: Inserm UMR1073, Nutrition, Gut and Brain Laboratory
Akio Inui: Kagoshima University Graduate School of Medical and Dental Sciences
Sergueï O. Fetissov: Inserm UMR1073, Nutrition, Gut and Brain Laboratory

Nature Communications, 2013, vol. 4, issue 1, 1-11

Abstract: Abstract Obese individuals often have increased appetite despite normal plasma levels of the main orexigenic hormone ghrelin. Here we show that ghrelin degradation in the plasma is inhibited by ghrelin-reactive IgG immunoglobulins, which display increased binding affinity to ghrelin in obese patients and mice. Co-administration of ghrelin together with IgG from obese individuals, but not with IgG from anorectic or control patients, increases food intake in rats. Similarly, chronic injections of ghrelin together with IgG from ob/ob mice increase food intake, meal frequency and total lean body mass of mice. These data reveal that in both obese humans and mice, IgG with increased affinity for ghrelin enhances ghrelin’s orexigenic effect, which may contribute to increased appetite and overeating.

Date: 2013
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms3685 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3685

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms3685

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().