A cholinergic trigger drives learning-induced plasticity at hippocampal synapses

Dai Mitsushima (), Akane Sano and Takuya Takahashi ()
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Dai Mitsushima: Yokohama City University Graduate School of Medicine
Akane Sano: Yokohama City University Graduate School of Medicine
Takuya Takahashi: Yokohama City University Graduate School of Medicine

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract Learning induces plastic changes in synapses. However, the regulatory molecules that orchestrate learning-induced synaptic changes are largely unknown. Although it is well established that cholinergic inputs from the medial septum modulate learning and memory, evidence for the cholinergic regulation of learning-induced synaptic plasticity is lacking. Here we find that the activation of muscarinic acetylcholine (ACh) receptors (mAChRs) mediates the contextual fear learning-driven strengthening of hippocampal excitatory pyramidal synapses through the synaptic incorporation of AMPA-type glutamate receptors (AMPARs). Contextual fear learning also enhances the strength of inhibitory synapses on hippocampal pyramidal CA1 neurons, in a manner mediated by the activation of, not mAChRs, but, nicotinic AChRs (nAChRs). We observe a significant correlation between the learning-induced increases in excitatory and inhibitory synaptic strength at individual pyramidal neurons. Understanding the mechanisms underlying cholinergic regulation of learning-induced hippocampal synaptic plasticity may help the development of new therapies for cognitive disorders.

Date: 2013
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DOI: 10.1038/ncomms3760

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