Arabidopsis SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity

Stefano Pietra, Anna Gustavsson, Christian Kiefer, Lothar Kalmbach, Per Hörstedt, Yoshihisa Ikeda, Anna N. Stepanova, Jose M. Alonso and Markus Grebe ()
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Stefano Pietra: Umeå Plant Science Centre, Umeå University
Anna Gustavsson: Umeå Plant Science Centre, Umeå University
Christian Kiefer: Umeå Plant Science Centre, Umeå University
Lothar Kalmbach: Umeå Plant Science Centre, Umeå University
Per Hörstedt: Umeå Core Facility Electron Microscopy, Umeå University
Yoshihisa Ikeda: Umeå Plant Science Centre, Umeå University
Anna N. Stepanova: North Carolina State University
Jose M. Alonso: North Carolina State University
Markus Grebe: Umeå Plant Science Centre, Umeå University

Nature Communications, 2013, vol. 4, issue 1, 1-15

Abstract: Abstract The orientation of cell division and the coordination of cell polarity within the plane of the tissue layer (planar polarity) contribute to shape diverse multicellular organisms. The root of Arabidopsis thaliana displays regularly oriented cell divisions, cell elongation and planar polarity providing a plant model system to study these processes. Here we report that the SABRE protein, which shares similarity with proteins of unknown function throughout eukaryotes, has important roles in orienting cell division and planar polarity. SABRE localizes at the plasma membrane, endomembranes, mitotic spindle and cell plate. SABRE stabilizes the orientation of CLASP-labelled preprophase band microtubules predicting the cell division plane, and of cortical microtubules driving cell elongation. During planar polarity establishment, sabre is epistatic to clasp at directing polar membrane domains of Rho-of-plant GTPases. Our findings mechanistically link SABRE to CLASP-dependent microtubule organization, shedding new light on the function of SABRE-related proteins in eukaryotes.

Date: 2013
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DOI: 10.1038/ncomms3779

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