Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer

Zuoren Yu, Liping Wang, Chenguang Wang, Xiaoming Ju, Min Wang, Ke Chen, Emanuele Loro, Zhiping Li, Yuzhen Zhang, Kongming Wu, Mathew C. Casimiro, Michael Gormley, Adam Ertel, Paolo Fortina, Yihan Chen, Aydin Tozeren, Zhongmin Liu and Richard G. Pestell ()
Additional contact information
Zuoren Yu: Thomas Jefferson University
Liping Wang: Thomas Jefferson University
Chenguang Wang: Thomas Jefferson University
Xiaoming Ju: Thomas Jefferson University
Min Wang: Thomas Jefferson University
Ke Chen: Thomas Jefferson University
Emanuele Loro: Thomas Jefferson University
Zhiping Li: Thomas Jefferson University
Yuzhen Zhang: Research Center for Translational Medicine, Key Laboratory for Basic Research in Cardiology, East Hospital, Tongji University School of Medicine
Kongming Wu: Thomas Jefferson University
Mathew C. Casimiro: Thomas Jefferson University
Michael Gormley: Thomas Jefferson University
Adam Ertel: Thomas Jefferson University
Paolo Fortina: Thomas Jefferson University
Yihan Chen: Research Center for Translational Medicine, Key Laboratory for Basic Research in Cardiology, East Hospital, Tongji University School of Medicine
Aydin Tozeren: Kimmel Cancer Center, Thomas Jefferson University
Zhongmin Liu: Research Center for Translational Medicine, Key Laboratory for Basic Research in Cardiology, East Hospital, Tongji University School of Medicine
Richard G. Pestell: Thomas Jefferson University

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates the pRB protein and promotes G1/S cell-cycle progression and oncogenesis. Dicer is a central regulator of miRNA maturation, encoding an enzyme that cleaves double-stranded RNA or stem–loop–stem RNA into 20–25 nucleotide long small RNA, governing sequence-specific gene silencing and heterochromatin methylation. The mechanism by which the cell cycle directly controls the non-coding genome is poorly understood. Here we show that cyclin D1−/− cells are defective in pre-miRNA processing which is restored by cyclin D1a rescue. Cyclin D1 induces Dicer expression in vitro and in vivo. Dicer is transcriptionally targeted by cyclin D1, via a cdk-independent mechanism. Cyclin D1 and Dicer expression significantly correlates in luminal A and basal-like subtypes of human breast cancer. Cyclin D1 and Dicer maintain heterochromatic histone modification (Tri-m-H3K9). Cyclin D1-mediated cellular proliferation and migration is Dicer-dependent. We conclude that cyclin D1 induction of Dicer coordinates microRNA biogenesis.

Date: 2013
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DOI: 10.1038/ncomms3812

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