Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

Thibaut Brunet, Adrien Bouclet, Padra Ahmadi, Démosthène Mitrossilis, Benjamin Driquez, Anne-Christine Brunet, Laurent Henry, Fanny Serman, Gaëlle Béalle, Christine Ménager, Frédéric Dumas-Bouchiat, Dominique Givord, Constantin Yanicostas, Damien Le-Roy, Nora M. Dempsey, Anne Plessis and Emmanuel Farge ()
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Thibaut Brunet: Mechanics and Genetics of Embryonic Development Group, PSL Research University, CNRS, UMR168, Inserm, Institut Curie
Adrien Bouclet: Mechanics and Genetics of Embryonic Development Group, PSL Research University, CNRS, UMR168, Inserm, Institut Curie
Padra Ahmadi: Mechanics and Genetics of Embryonic Development Group, PSL Research University, CNRS, UMR168, Inserm, Institut Curie
Démosthène Mitrossilis: Mechanics and Genetics of Embryonic Development Group, PSL Research University, CNRS, UMR168, Inserm, Institut Curie
Benjamin Driquez: Mechanics and Genetics of Embryonic Development Group, PSL Research University, CNRS, UMR168, Inserm, Institut Curie
Anne-Christine Brunet: Mechanics and Genetics of Embryonic Development Group, PSL Research University, CNRS, UMR168, Inserm, Institut Curie
Laurent Henry: Mechanics and Genetics of Embryonic Development Group, PSL Research University, CNRS, UMR168, Inserm, Institut Curie
Fanny Serman: Mechanics and Genetics of Embryonic Development Group, PSL Research University, CNRS, UMR168, Inserm, Institut Curie
Gaëlle Béalle: Physico-Chemistry of Electrolytes and Colloïds, CNRS UMR 7195—UPMC—ESPCI
Christine Ménager: Physico-Chemistry of Electrolytes and Colloïds, CNRS UMR 7195—UPMC—ESPCI
Frédéric Dumas-Bouchiat: Univ. Grenoble Alpes, Inst NEEL
Dominique Givord: Univ. Grenoble Alpes, Inst NEEL
Constantin Yanicostas: Zebrafish Models of Neurodegenerative Disorders, Inserm, Hôpital Robert Debré
Damien Le-Roy: Univ. Grenoble Alpes, Inst NEEL
Nora M. Dempsey: Univ. Grenoble Alpes, Inst NEEL
Anne Plessis: Institut Jacques Monod, CNRS, UMR 7592, Univ Paris Diderot, Sorbonne Paris Cité
Emmanuel Farge: Mechanics and Genetics of Embryonic Development Group, PSL Research University, CNRS, UMR168, Inserm, Institut Curie

Nature Communications, 2013, vol. 4, issue 1, 1-15

Abstract: Abstract The modulation of developmental biochemical pathways by mechanical cues is an emerging feature of animal development, but its evolutionary origins have not been explored. Here we show that a common mechanosensitive pathway involving β-catenin specifies early mesodermal identity at gastrulation in zebrafish and Drosophila. Mechanical strains developed by zebrafish epiboly and Drosophila mesoderm invagination trigger the phosphorylation of β-catenin–tyrosine-667. This leads to the release of β-catenin into the cytoplasm and nucleus, where it triggers and maintains, respectively, the expression of zebrafish brachyury orthologue notail and of Drosophila Twist, both crucial transcription factors for early mesoderm identity. The role of the β-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila. This suggests mesoderm mechanical induction dating back to at least the last bilaterian common ancestor more than 570 million years ago, the period during which mesoderm is thought to have emerged.

Date: 2013
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DOI: 10.1038/ncomms3821

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