A genome-wide regulatory network identifies key transcription factors for memory CD8+ T-cell development

Guangan Hu and Jianzhu Chen ()
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Guangan Hu: Massachusetts Institute of Technology
Jianzhu Chen: Massachusetts Institute of Technology

Nature Communications, 2013, vol. 4, issue 1, 1-14

Abstract: Abstract Memory CD8+ T-cell development is defined by the expression of a specific set of memory signature genes. Despite recent progress, many components of the transcriptional control of memory CD8+ T-cell development are still unknown. To identify transcription factors and their interactions in memory CD8+ T-cell development, we construct a genome-wide regulatory network and apply it to identify key transcription factors that regulate memory signature genes. Most of the known transcription factors having a role in memory CD8+ T-cell development are rediscovered and about a dozen new ones are also identified. Sox4, Bhlhe40, Bach2 and Runx2 are experimentally verified, and Bach2 is further shown to promote both development and recall proliferation of memory CD8+ T cells through Prdm1 and Id3. Gene perturbation study identifies the interactions between the transcription factors, with Sox4 positioned as a hub. The identified transcription factors and insights into their interactions should facilitate further dissection of molecular mechanisms underlying memory CD8+ T-cell development.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3830

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DOI: 10.1038/ncomms3830

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