A hyperpolarized equilibrium for magnetic resonance

Jan-Bernd Hövener (), Niels Schwaderlapp, Thomas Lickert, Simon B. Duckett, Ryan E. Mewis, Louise A. R. Highton, Stephen M. Kenny, Gary G. R. Green, Dieter Leibfritz, Jan G. Korvink, Jürgen Hennig and Dominik von Elverfeldt
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Jan-Bernd Hövener: German Consortium for Cancer Research (DKTK)
Niels Schwaderlapp: Medical Physics, University Medical Center Freiburg
Thomas Lickert: Medical Physics, University Medical Center Freiburg
Simon B. Duckett: Centre for Hyperpolarisation in Magnetic Resonance, University of York
Ryan E. Mewis: Centre for Hyperpolarisation in Magnetic Resonance, University of York
Louise A. R. Highton: Centre for Hyperpolarisation in Magnetic Resonance, University of York
Stephen M. Kenny: Centre for Hyperpolarisation in Magnetic Resonance, University of York
Gary G. R. Green: Centre for Hyperpolarisation in Magnetic Resonance, University of York
Dieter Leibfritz: Medical Physics, University Medical Center Freiburg
Jan G. Korvink: Universität Freiburg
Jürgen Hennig: Medical Physics, University Medical Center Freiburg
Dominik von Elverfeldt: Medical Physics, University Medical Center Freiburg

Nature Communications, 2013, vol. 4, issue 1, 1-5

Abstract: Abstract Nuclear magnetic resonance spectroscopy and imaging (MRI) play an indispensable role in science and healthcare but use only a tiny fraction of their potential. No more than ≈10 p.p.m. of all 1H nuclei are effectively detected in a 3-Tesla clinical MRI system. Thus, a vast array of new applications lays dormant, awaiting improved sensitivity. Here we demonstrate the continuous polarization of small molecules in solution to a level that cannot be achieved in a viable magnet. The magnetization does not decay and is effectively reinitialized within seconds after being measured. This effect depends on the long-lived, entangled spin-order of parahydrogen and an exchange reaction in a low magnetic field of 10−3 Tesla. We demonstrate the potential of this method by fast MRI and envision the catalysis of new applications such as cancer screening or indeed low-field MRI for routine use and remote application.

Date: 2013
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DOI: 10.1038/ncomms3946

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