Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T-cell development

Jie Li, Zhijie Liu, Shiyun Xiao and Nancy R. Manley ()
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Jie Li: University of Georgia
Zhijie Liu: University of Georgia
Shiyun Xiao: University of Georgia
Nancy R. Manley: University of Georgia

Nature Communications, 2013, vol. 4, issue 1, 1-8

Abstract: Abstract The thoracic thymus is the primary vertebrate organ for T-cell generation. Accessory cervical thymi have also been identified in humans and mice, and shown in mice to be independent functional organs that support T-cell development. However, their origin and functional significance remain unclear. Here we show that cervical thymi in mice have following two origins: delayed differentiation of endodermal precursors and transdifferentiation of parathyroid-fated cells. Compared with thoracic thymus, parathyroid-origin cervical thymi (pCT) express low levels of the thymic epithelial cell-specific transcription factor FOXN1. Consequently, pCT form a distinct microenvironment that supports an atypical thymocyte development pathway, generating T cells with unconventional phenotypic characteristics. Our data demonstrate a transdifferentiation origin for a subset of cervical thymi, with specific functional consequences for T-cell development.

Date: 2013
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DOI: 10.1038/ncomms3959

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