Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne

Li He (), Wen-Juan Wu, Jian-Kang Yang, Hui Cheng, Xian-Bo Zuo, Wei Lai, Tian-Wen Gao, Cui-Lin Ma, Na Luo, Jian-Qing Huang, Feng-Yan Lu, Ye-Qiang Liu, Yi-Jin Huang, Qian-Jin Lu, Huai-Liang Zhang, Lin Wang, Wei-Zhen Wang, Mei-Mei Wang, Sheng-Xiang Xiao, Qing Sun, Chun-Yang Li, Yan-Ping Bai, Hui Li, Zhan-Chao Zhou, Fu-Sheng Zhou, Gang Chen, Bo Liang, Jue Qi, Xiao-Yan Yang, Ting Yang, Xing Zheng, Liang-Dan Sun, Xue-Jun Zhang and Ya-Ping Zhang ()
Additional contact information
Li He: First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province
Wen-Juan Wu: First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province
Jian-Kang Yang: Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University
Hui Cheng: Anhui Medical University
Xian-Bo Zuo: Anhui Medical University
Wei Lai: the Third Affiliated Hospital of Sun Yat-sen University
Tian-Wen Gao: Xijing Hospital, Fourth Military Medical University
Cui-Lin Ma: Xijing Hospital, Fourth Military Medical University
Na Luo: Southwest Hospital, Third Military Medical University
Jian-Qing Huang: Fuzhou Dermatosis Prevention Hospital
Feng-Yan Lu: Kunming Medical University Affiliated Hospital Qujing (Qujing First People’s Hospital)
Ye-Qiang Liu: Shanghai Dermatology Hospital
Yi-Jin Huang: the First Affiliated Hospital of Xiamen University & the First Hospital of Xiamen
Qian-Jin Lu: Second Xiangya Hospital, Central South University
Huai-Liang Zhang: Institute of Dermatology, Peking Union Medical College and Chinese Academy of Medical Sciences
Lin Wang: West China Hospital of Sichuan University
Wei-Zhen Wang: Wuhan No.1 Hospital
Mei-Mei Wang: First Affiliated Hospital of Baotou Medical College
Sheng-Xiang Xiao: Second Affiliated Hospital of Xi’an Jiaotong University
Qing Sun: Qilu Hospital of Shandong University
Chun-Yang Li: Qilu Hospital of Shandong University
Yan-Ping Bai: China-Japan Friendship hospital
Hui Li: the First Affiliated Hospital of Chongqing Medical University
Zhan-Chao Zhou: Winona medical cosmetic center
Fu-Sheng Zhou: Anhui Medical University
Gang Chen: Anhui Medical University
Bo Liang: Anhui Medical University
Jue Qi: First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province
Xiao-Yan Yang: First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province
Ting Yang: First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province
Xing Zheng: State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences
Liang-Dan Sun: Anhui Medical University
Xue-Jun Zhang: Anhui Medical University
Ya-Ping Zhang: State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences

Nature Communications, 2014, vol. 5, issue 1, 1-7

Abstract: Abstract Severe acne is a chronic inflammatory skin disorder characterized by widespread inflammatory lesions including nodules, cysts and potential scarring. Here we perform the first genome-wide association study of severe acne in a Chinese Han population comprising 1,056 cases and 1,056 controls using the Illumina HumanOmniZhongHua-8 BeadChip. In an independent cohort of 1,860 cases and 3,660 controls of Chinese Han, we replicate 101 SNPs of which 3 showed consistent association. We identify two new susceptibility loci at 11p11.2 (DDB2, rs747650, Pcombined=4.41 × 10−9 and rs1060573, Pcombined=1.28 × 10−8) and 1q24.2 (SELL, rs7531806, Pcombined=1.20 × 10−8) that are involved in androgen metabolism, inflammation processes and scar formation in severe acne. These results point to new genetic susceptibility factors and suggest several new biological pathways related to severe acne.

Date: 2014
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DOI: 10.1038/ncomms3870

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