Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil

Raluca M. Fratila, M. Victoria Gomez, Stanislav Sýkora and Aldrik H. Velders ()
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Raluca M. Fratila: Laboratory of SupraMolecular Chemistry & Technology, University of Twente
M. Victoria Gomez: Instituto Regional de Investigación Científica Aplicada (IRICA), Universidad de Castilla-La Mancha, Avda. Camilo José Cela, s/n
Stanislav Sýkora: Extra Byte, Via Raffaello Sanzio 22C
Aldrik H. Velders: Laboratory of SupraMolecular Chemistry & Technology, University of Twente

Nature Communications, 2014, vol. 5, issue 1, 1-8

Abstract: Abstract Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical technique, but its low sensitivity and highly sophisticated, costly, equipment severely constrain more widespread applications. Here we show that a non-resonant planar transceiver microcoil integrated in a microfluidic chip (detection volume 25 nl) can detect different nuclides in the full broad-band range of Larmor frequencies (at 9.4 T from 61 to 400 MHz). Routine one-dimensional (1D) and two-dimensional (2D), homo- and heteronuclear experiments can be carried out using the broad-band coil set-up. Noteworthy, heteronuclear 2D experiments can be performed in a straightforward manner on virtually any combination of nuclides (from classical 1H–13C to more exotic combinations like 19F–31P) both in coupled and decoupled mode. Importantly, the concept of a non-resonant system provides magnetic field-independent NMR probes; moreover, the small-volume alleviates problems related to field inhomogeneity, making the broad-band coil an attractive option for, for example, portable and table-top NMR systems.

Date: 2014
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DOI: 10.1038/ncomms4025

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