MED18 interaction with distinct transcription factors regulates multiple plant functions

Zhibing Lai, Craig M. Schluttenhofer, Ketaki Bhide, Jacob Shreve, Jyothi Thimmapuram, Sang Yeol Lee, Dae-Jin Yun and Tesfaye Mengiste ()
Additional contact information
Zhibing Lai: Purdue University
Craig M. Schluttenhofer: Purdue University
Ketaki Bhide: Bioinformatics Core, Cyber Center, Discovery Park, Purdue University
Jacob Shreve: Bioinformatics Core, Cyber Center, Discovery Park, Purdue University
Jyothi Thimmapuram: Bioinformatics Core, Cyber Center, Discovery Park, Purdue University
Sang Yeol Lee: Gyeongsang National University
Dae-Jin Yun: Gyeongsang National University
Tesfaye Mengiste: Purdue University

Nature Communications, 2014, vol. 5, issue 1, 1-14

Abstract: Abstract Mediator is an evolutionarily conserved transcriptional regulatory complex. Mechanisms of Mediator function are poorly understood. Here we show that Arabidopsis MED18 is a multifunctional protein regulating plant immunity, flowering time and responses to hormones through interactions with distinct transcription factors. MED18 interacts with YIN YANG1 to suppress disease susceptibility genes glutaredoxins GRX480, GRXS13 and thioredoxin TRX-h5. Consequently, yy1 and med18 mutants exhibit deregulated expression of these genes and enhanced susceptibility to fungal infection. In addition, MED18 interacts with ABA INSENSITIVE 4 and SUPPRESSOR OF FRIGIDA4 to regulate abscisic acid responses and flowering time, respectively. MED18 associates with the promoter, coding and terminator regions of target genes suggesting its function in transcription initiation, elongation and termination. Notably, RNA polymerase II occupancy and histone H3 lysine tri-methylation of target genes are affected in the med18 mutant, reinforcing MED18 function in different mechanisms of transcriptional control. Overall, MED18 conveys distinct cues to engender transcription underpinning plant responses.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms4064 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4064

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4064

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().