Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle

Daniel L. J. Thorek, David Ulmert, Ndeye-Fatou M. Diop, Mihaela E. Lupu, Michael G. Doran, Ruimin Huang, Diane S. Abou, Steven M. Larson and Jan Grimm ()
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Daniel L. J. Thorek: The Johns Hopkins School of Medicine
David Ulmert: Memorial Sloan-Kettering Cancer Center (MSKCC)
Ndeye-Fatou M. Diop: The City College of New York
Mihaela E. Lupu: Memorial Sloan-Kettering Cancer Center (MSKCC)
Michael G. Doran: Memorial Sloan-Kettering Cancer Center (MSKCC)
Ruimin Huang: Memorial Sloan-Kettering Cancer Center (MSKCC)
Diane S. Abou: The Johns Hopkins School of Medicine
Steven M. Larson: Memorial Sloan-Kettering Cancer Center (MSKCC)
Jan Grimm: Memorial Sloan-Kettering Cancer Center (MSKCC)

Nature Communications, 2014, vol. 5, issue 1, 1-9

Abstract: Abstract The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with 99mTc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, 89Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that 89Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging.

Date: 2014
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DOI: 10.1038/ncomms4097

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