Complex self-assembly of pyrimido[4,5-d]pyrimidine nucleoside supramolecular structures

Hang Zhao, Xiurong Guo, Shiliang He, Xin Zeng, Xinglong Zhou, Chaoliang Zhang, Jing Hu, Xiaohua Wu, Zhihua Xing, Liangyin Chu, Yang He () and Qianming Chen ()
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Hang Zhao: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University
Xiurong Guo: Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University
Shiliang He: Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University
Xin Zeng: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University
Xinglong Zhou: Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University
Chaoliang Zhang: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University
Jing Hu: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University
Xiaohua Wu: Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University
Zhihua Xing: Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University
Liangyin Chu: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University
Yang He: Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University
Qianming Chen: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract Supramolecular self-assembly is not only one of the chemical roots of biological structure but is also drawing attention in different industrial fields. Here we study the mechanism of the formation of a complex flower-shaped supramolecular structure of pyrimido[4,5-d]pyrimidine nucleosides by dynamic light scattering, scanning electron microscopy, differential scanning calorimetry, nuclear magnetic resonance and X-ray analysis. Upon removing the hydroxyl group of sugars, different flower-shaped superstructures can be produced. These works demonstrate that complex self-assembly can indeed be attained through hierarchical non-covalent interactions of single molecules. Furthermore, chimerical structures built from molecular recognition by these monomers indicate their potential in other fields if combined with other chemical entities.

Date: 2014
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DOI: 10.1038/ncomms4108

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