The central role of EED in the orchestration of polycomb group complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran and Arul M. Chinnaiyan ()
Additional contact information
Qi Cao: Michigan Center for Translational Pathology, University of Michigan Medical School
Xiaoju Wang: Michigan Center for Translational Pathology, University of Michigan Medical School
Meng Zhao: Emory University
Rendong Yang: Emory University
Rohit Malik: Michigan Center for Translational Pathology, University of Michigan Medical School
Yuanyuan Qiao: Michigan Center for Translational Pathology, University of Michigan Medical School
Anton Poliakov: Michigan Center for Translational Pathology, University of Michigan Medical School
Anastasia K. Yocum: Michigan Center for Translational Pathology, University of Michigan Medical School
Yong Li: Michigan Center for Translational Pathology, University of Michigan Medical School
Wei Chen: Michigan Center for Translational Pathology, University of Michigan Medical School
Xuhong Cao: Michigan Center for Translational Pathology, University of Michigan Medical School
Xia Jiang: Michigan Center for Translational Pathology, University of Michigan Medical School
Arun Dahiya: Michigan Center for Translational Pathology, University of Michigan Medical School
Clair Harris: University of Michigan Medical School
Felix Y. Feng: Michigan Center for Translational Pathology, University of Michigan Medical School
Sundeep Kalantry: University of Michigan Medical School
Zhaohui S. Qin: Emory University
Saravana M. Dhanasekaran: Michigan Center for Translational Pathology, University of Michigan Medical School
Arul M. Chinnaiyan: Michigan Center for Translational Pathology, University of Michigan Medical School

Nature Communications, 2014, vol. 5, issue 1, 1-13

Abstract: Abstract Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. EED functions to recruit PRC1 to H3K27me3 loci and enhances PRC1-mediated H2A ubiquitin E3 ligase activity. Taken together, we suggest an integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2.

Date: 2014
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DOI: 10.1038/ncomms4127

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