MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

Michito Hamada (), Megumi Nakamura, Mai Thi Nhu Tran, Takashi Moriguchi, Cynthia Hong, Takayuki Ohsumi, Tra Thi Huong Dinh, Manabu Kusakabe, Motochika Hattori, Tokio Katsumata, Satoko Arai, Katsuhiko Nakashima, Takashi Kudo, Etsushi Kuroda, Chien-Hui Wu, Pei-Han Kao, Masaharu Sakai, Hitoshi Shimano, Toru Miyazaki, Peter Tontonoz and Satoru Takahashi ()
Additional contact information
Michito Hamada: University of Tsukuba, 1-1-1, Tennodai
Megumi Nakamura: University of Tsukuba, 1-1-1, Tennodai
Mai Thi Nhu Tran: University of Tsukuba, 1-1-1, Tennodai
Takashi Moriguchi: Tohoku University Graduate School of Medicine
Cynthia Hong: Howard Hughes Medical Institute, University of California
Takayuki Ohsumi: University of Tsukuba, 1-1-1, Tennodai
Tra Thi Huong Dinh: Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai
Manabu Kusakabe: University of Tsukuba, 1-1-1, Tennodai
Motochika Hattori: University of Tsukuba, 1-1-1, Tennodai
Tokio Katsumata: University of Tsukuba, 1-1-1, Tennodai
Satoko Arai: Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku
Katsuhiko Nakashima: Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku
Takashi Kudo: University of Tsukuba, 1-1-1, Tennodai
Etsushi Kuroda: Laboratory of Vaccine Science, WPI Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamada-oka
Chien-Hui Wu: National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Jhong-Shan South Road
Pei-Han Kao: Chang Gung Memorial Hospital, No. 199, Tung-Hwa North Road
Masaharu Sakai: Faculty of Health Sciences, Hokkaido University, N12, W5, Kita-ku
Hitoshi Shimano: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1, Tennodai
Toru Miyazaki: Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku
Peter Tontonoz: Tohoku University Graduate School of Medicine
Satoru Takahashi: University of Tsukuba, 1-1-1, Tennodai

Nature Communications, 2014, vol. 5, issue 1, 1-14

Abstract: Abstract MafB is a transcription factor that induces myelomonocytic differentiation. However, the precise role of MafB in the pathogenic function of macrophages has never been clarified. Here we demonstrate that MafB promotes hyperlipidemic atherosclerosis by suppressing foam-cell apoptosis. Our data show that MafB is predominantly expressed in foam cells found within atherosclerotic lesions, where MafB mediates the oxidized LDL-activated LXR/RXR-induced expression of apoptosis inhibitor of macrophages (AIM). In the absence of MafB, activated LXR/RXR fails to induce the expression of AIM, a protein that is normally responsible for protecting macrophages from apoptosis; thus, Mafb-deficient macrophages are prone to apoptosis. Haematopoietic reconstitution with Mafb-deficient fetal liver cells in recipient LDL receptor-deficient hyperlipidemic mice revealed accelerated foam-cell apoptosis, which subsequently led to the attenuation of the early atherogenic lesion. These findings represent the first evidence that the macrophage-affiliated MafB transcription factor participates in the acceleration of atherogenesis.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms4147 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4147

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4147

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().