Maspin is not required for embryonic development or tumour suppression

Sonia S. Y. Teoh, Jessica Vieusseux, Monica Prakash, Susan Berkowicz, Jennii Luu, Catherina H. Bird, Ruby H. P. Law, Carlos Rosado, John T. Price, James C. Whisstock () and Phillip I. Bird ()
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Sonia S. Y. Teoh: School of Biomedical Sciences, Monash University
Jessica Vieusseux: School of Biomedical Sciences, Monash University
Monica Prakash: School of Biomedical Sciences, Monash University
Susan Berkowicz: School of Biomedical Sciences, Monash University
Jennii Luu: School of Biomedical Sciences, Monash University
Catherina H. Bird: School of Biomedical Sciences, Monash University
Ruby H. P. Law: School of Biomedical Sciences, Monash University
Carlos Rosado: School of Biomedical Sciences, Monash University
John T. Price: School of Biomedical Sciences, Monash University
James C. Whisstock: School of Biomedical Sciences, Monash University
Phillip I. Bird: School of Biomedical Sciences, Monash University

Nature Communications, 2014, vol. 5, issue 1, 1-9

Abstract: Abstract Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers. Consistent with a critical role in development or differentiation maspin knockout mice die during early embryogenesis, yet clinical data conflict on the prognostic utility of maspin expression. Here to reconcile these findings we made conditional knockout mice. Surprisingly, maspin knockout embryos develop into overtly normal animals. Contrary to original reports, maspin re-expression does not inhibit tumour growth or metastasis in vivo, or influence cell migration, invasion or survival in vitro. Bioinformatic analyses reveal that maspin is not commonly under-expressed in cancer, and that perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression.

Date: 2014
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DOI: 10.1038/ncomms4164

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