The origin of segmentation motor activity in the intestine

Jan D. Huizinga (), Ji-Hong Chen, Yong Fang Zhu, Andrew Pawelka, Ryan J. McGinn, Berj L. Bardakjian, Sean P. Parsons, Wolfgang A. Kunze, Richard You Wu, Premysl Bercik, Amir Khoshdel, Sifeng Chen, Sheng Yin, Qian Zhang, Yuanjie Yu, Qingmin Gao, Kongling Li, Xinghai Hu, Natalia Zarate, Phillip Collins, Marc Pistilli, Junling Ma, Ruixue Zhang and David Chen
Additional contact information
Jan D. Huizinga: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
Ji-Hong Chen: Wuhan University, Renmin Hospital
Yong Fang Zhu: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
Andrew Pawelka: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
Ryan J. McGinn: Brain Body Institute, St Joseph’s Hospital, McMaster University
Berj L. Bardakjian: Brain Body Institute, St Joseph’s Hospital, McMaster University
Sean P. Parsons: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
Wolfgang A. Kunze: Institute of Biomaterial and Biomedical Engineering and the Neuroscience Program at the University of Toronto
Richard You Wu: Institute of Biomaterial and Biomedical Engineering and the Neuroscience Program at the University of Toronto
Premysl Bercik: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
Amir Khoshdel: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
Sifeng Chen: Wuhan University, Renmin Hospital
Sheng Yin: Wuhan University, Renmin Hospital
Qian Zhang: Wuhan University, Renmin Hospital
Yuanjie Yu: Wuhan University, Renmin Hospital
Qingmin Gao: Wuhan University, Renmin Hospital
Kongling Li: Wuhan University, Renmin Hospital
Xinghai Hu: Huazhong University of Science and Technology
Natalia Zarate: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
Phillip Collins: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
Marc Pistilli: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
Junling Ma: University of Victoria
Ruixue Zhang: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University
David Chen: Faculty of Health Sciences, Farncombe Family Digestive Health Research Institute, McMaster University

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract The segmentation motor activity of the gut that facilitates absorption of nutrients was first described in the late 19th century, but the fundamental mechanisms underlying it remain poorly understood. The dominant theory suggests alternate excitation and inhibition from the enteric nervous system. Here we demonstrate that typical segmentation can occur after total nerve blockade. The segmentation motor pattern emerges when the amplitude of the dominant pacemaker, the slow wave generated by interstitial cells of Cajal associated with the myenteric plexus (ICC-MP), is modulated by the phase of induced lower frequency rhythmic transient depolarizations, generated by ICC associated with the deep muscular plexus (ICC-DMP), resulting in a waxing and waning of the amplitude of the slow wave and a rhythmic checkered pattern of segmentation motor activity. Phase–amplitude modulation of the slow waves points to an underlying system of coupled nonlinear oscillators originating in the networks of ICC.

Date: 2014
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms4326 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4326

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4326

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().