FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

Beatriz León, John E. Bradley, Frances E. Lund, Troy D. Randall and André Ballesteros-Tato ()
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Beatriz León: University of Alabama at Birmingham
John E. Bradley: University of Alabama at Birmingham
Frances E. Lund: University of Alabama at Birmingham
Troy D. Randall: University of Alabama at Birmingham
André Ballesteros-Tato: University of Alabama at Birmingham

Nature Communications, 2014, vol. 5, issue 1, 1-10

Abstract: Abstract Here, we test the role of FoxP3+ regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza. In contrast to the idea that Tregs suppress T-cell responses, we find that Treg depletion severely reduces the Tfh cell response to influenza virus. Furthermore, Treg depletion prevents the accumulation of influenza-specific GCs. These effects are not due to alterations in TGFβ availability or a precursor–progeny relationship between Tregs and Tfh cells, but are instead mediated by increased availability of IL-2, which suppresses the differentiation of Tfh cells and as a consequence, compromises the GC B response. Thus, Tregs promote influenza-specific GC responses by preventing excessive IL-2 signalling, which suppresses Tfh cell differentiation.

Date: 2014
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DOI: 10.1038/ncomms4495

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