EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1

Yon Ju Ji, Yoo-Seok Hwang, Kathleen Mood, Hee-Jun Cho, Hyun-Shik Lee, Emily Winterbottom, Hélène Cousin and Ira O. Daar ()
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Yon Ju Ji: Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick
Yoo-Seok Hwang: Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick
Kathleen Mood: Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick
Hee-Jun Cho: Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick
Hyun-Shik Lee: ABRC, CMRI, School of Life Sciences, College of Natural Sciences, Kyungpook National University
Emily Winterbottom: Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick
Hélène Cousin: University of Massachusetts
Ira O. Daar: Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick

Nature Communications, 2014, vol. 5, issue 1, 1-15

Abstract: Abstract The Eph/ephrin signalling pathways have a critical function in cell adhesion and repulsion, and thus play key roles in various morphogenetic events during development. Here we show that a decrease in ephrinB2 protein causes neural tube closure defects during Xenopus laevis embryogenesis. Such a decrease in ephrinB2 protein levels is observed on the loss of flotillin-1 scaffold protein, a newly identified ephrinB2-binding partner. This dramatic decline in ephrinB2 protein levels on the absence of flotillin-1 expression is specific, and is partly the result of an increased susceptibility to cleavage by the metalloprotease ADAM10. These findings indicate that flotillin-1 regulates ephrinB2 protein levels through ADAM10, and is required for appropriate neural tube morphogenesis in the Xenopus embryo.

Date: 2014
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DOI: 10.1038/ncomms4516

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