Porphyrin–phospholipid liposomes permeabilized by near-infrared light

Kevin A. Carter, Shuai Shao, Matthew I. Hoopes, Dandan Luo, Bilal Ahsan, Vladimir M. Grigoryants, Wentao Song, Haoyuan Huang, Guojian Zhang, Ravindra K. Pandey, Jumin Geng, Blaine A. Pfeifer, Charles P. Scholes, Joaquin Ortega, Mikko Karttunen and Jonathan F. Lovell ()
Additional contact information
Kevin A. Carter: University at Buffalo, State University of New York
Shuai Shao: University at Buffalo, State University of New York
Matthew I. Hoopes: University of Waterloo
Dandan Luo: University at Buffalo, State University of New York
Bilal Ahsan: McMaster University
Vladimir M. Grigoryants: University at Albany, State University of New York
Wentao Song: University at Buffalo, State University of New York
Haoyuan Huang: University at Buffalo, State University of New York
Guojian Zhang: University at Buffalo, State University of New York
Ravindra K. Pandey: PDT Center, Roswell Park Cancer Institute
Jumin Geng: University at Buffalo, State University of New York
Blaine A. Pfeifer: University at Buffalo, State University of New York
Charles P. Scholes: University at Albany, State University of New York
Joaquin Ortega: McMaster University
Mikko Karttunen: University of Waterloo
Jonathan F. Lovell: University at Buffalo, State University of New York

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract The delivery of therapeutic compounds to target tissues is a central challenge in treating disease. Externally controlled drug release systems hold potential to selectively enhance localized delivery. Here we describe liposomes doped with porphyrin–phospholipid that are permeabilized directly by near-infrared light. Molecular dynamics simulations identified a novel light-absorbing monomer esterified from clinically approved components predicted and experimentally demonstrated to give rise to a more stable porphyrin bilayer. Light-induced membrane permeabilization is enabled with liposomal inclusion of 10 molar % porphyrin–phospholipid and occurs in the absence of bulk or nanoscale heating. Liposomes reseal following laser exposure and permeability is modulated by varying porphyrin–phospholipid doping, irradiation intensity or irradiation duration. Porphyrin–phospholipid liposomes demonstrate spatial control of release of entrapped gentamicin and temporal control of release of entrapped fluorophores following intratumoral injection. Following systemic administration, laser irradiation enhances deposition of actively loaded doxorubicin in mouse xenografts, enabling an effective single-treatment antitumour therapy.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms4546 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4546

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4546

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().