Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Ricki J. Colman, T. Mark Beasley, Joseph W. Kemnitz, Sterling C. Johnson, Richard Weindruch and Rozalyn M. Anderson ()
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Ricki J. Colman: Wisconsin National Primate Research Center, University of Wisconsin
T. Mark Beasley: Geriatrics Research, Education and Clinical Center, Birmingham/Atlanta Veterans Administration Hospital
Joseph W. Kemnitz: University of Wisconsin
Sterling C. Johnson: Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital
Richard Weindruch: Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital
Rozalyn M. Anderson: Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital

Nature Communications, 2014, vol. 5, issue 1, 1-5

Abstract: Abstract Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR’s effects in primates. Here we show that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood. These data contrast with observations in the 2012 NIA intramural study report, where a difference in survival was not detected between control-fed and CR monkeys. A comparison of body weight of control animals from both studies with each other, and against data collected in a multi-centred relational database of primate ageing, suggests that the NIA control monkeys were effectively undergoing CR. Our data indicate that the benefits of CR on ageing are conserved in primates.

Date: 2014
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DOI: 10.1038/ncomms4557

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